Isoflavone metabolites

Details Isoflavone metabolites Isoflavone metabolites

C - Chemistry, Metallurgy

12

N

C12N 1/20 (2006.01) A61K 31/352 (2006.01) A61K 35/74 (2006.01) C12N 1/00 (2006.01) C12P 7/26 (2006.01) C12P 17/06 (2006.01)

Patent

CA 2727692

There are disclosed compounds of formulae (I) or (II) in which A is selected from the group consisting of (1), (2), (3) and (4); OH, and one of R1 and R2 is selected from H, OH and OCH3, and the other of R1 and R2 is selected from OH and OCH3; one of R3 and R4 is selected from H, OH and OCH3, and the other of R3 and R4 is selected from OH and OCH3; provided that at least one of the pairs R1, R2 and R3, R4 are both OH; R5 is selected from OH and OCH3; and ~ denotes a single or double bond; and pharmaceutically acceptable salts and prodrugs thereof. The compounds of the invention are useful for the treatment of hormone-dependent conditions and cancers. (See formula I) (See formula II) (See formula 1) (See formula 2) (See formula 3) (See formula 4)

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