Isoflavonoids for treatment and prevention of alzheimer...

A - Human Necessities – 61 – K

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A61K 9/08 (2006.01) A61K 9/14 (2006.01) A61K 9/20 (2006.01) A61K 9/48 (2006.01) A61K 31/12 (2006.01) A61K 31/35 (2006.01) A61K 31/352 (2006.01) A61K 31/353 (2006.01)

Patent

CA 2274839

A method of treating or preventing, in a human patient, dementia of Alzheimer type, or age-related loss of cognitive function, said method comprising administering to said patient an isolated isoflavonoid selected from the group consisting of genistein, daidzein, biochanin A, formononetin, O- desmethylangolensin, glycitin, and equol, in an amount sufficient to produce a transient isoflavonoid concentration in the bloodstream of said patient of at least 100 nanomoles/L.

L'invention concerne un procédé destiné à traiter ou à prévenir, chez un patient humain, la démence de type Alzheimer ou la perte de ses facultés cognitives due à l'âge, ce procédé comprenant l'administration audit patient d'un isoflavonoïde isolé choisi dans le groupe composé de la génistéine, de la daidzéine, de la biochanine A, de la formo-ononétine, de l'O-desméthyl-angolensine, de la glycitine, et de l'équol, cet isoflavonoïde étant administré en quantité suffisante pour produire une concentration transitoire d'isoflavonoïde d'au moins 100 nanomoles/l dans la circulation sanguine dudit patient.

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