Isoform-selective hdac inhibitors

Details Isoform-selective hdac inhibitors Isoform-selective hdac inhibitors

C - Chemistry, Metallurgy

07

D

C07D 417/12 (2006.01) A61K 31/167 (2006.01) A61K 31/27 (2006.01) A61K 31/401 (2006.01) A61K 31/405 (2006.01) A61K 31/426 (2006.01) A61K 31/427 (2006.01) A61P 35/00 (2006.01) C07C 259/06 (2006.01) C07C 271/28 (2006.01) C07C 323/60 (2006.01) C07D 207/16 (2006.01) C07D 209/20 (2006.01) C07D 277/46 (2006.01)

Patent

CA 2659478

One aspect of the invention relates to isoform-selective HDAC inhibitors. Also provided are methods of sensitizing a cancer cell to the cytotoxic effects of radiotherapy. The invention also provides methods for treating cancer, methods for treating neurological diseases and methods for treating malaria. Additionally, the invention provides pharmaceutical compositions comprising an HDAC inhibitor of the invention; and kits comprising a an HDAC inhibitor of the invention.

Un aspect de l'invention concerne des inhibiteurs HDAC sélectifs d'une isoforme. L'invention concerne en outre des procédés de sensibilisation d'une cellule cancéreuse aux effets cytotoxiques d'une radiothérapie. L'invention concerne également des procédés permettant de traiter le cancer, des procédés permettant de traiter des maladies neurologiques et des procédés permettant de traiter la malaria. De plus, l'invention concerne des compositions pharmaceutiques contenant in inhibiteur HPAC selon l'invention ainsi que des trousses contenant un inhibiteur HDAC selon l'invention.

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