Isoforms of human calcium sensing receptor

Details Isoforms of human calcium sensing receptor Isoforms of human calcium sensing receptor

C - Chemistry, Metallurgy

12

N

C12N 15/12 (2006.01) A61K 38/17 (2006.01) A61K 39/395 (2006.01) A61K 47/48 (2006.01) C07K 14/705 (2006.01) C07K 14/72 (2006.01) C07K 16/28 (2006.01) C12N 5/00 (2006.01) C12N 5/10 (2006.01) C12N 15/10 (2006.01) C12N 15/63 (2006.01) C12P 19/34 (2006.01) C12Q 1/68 (2006.01)

Patent

CA 2336543

The present invention relates to isoforms of a human calcium sensing receptor, and to the genes encoding these isoforms. The invention further relates to methods of screening for agonists or antagonists of the isoforms, particularly with respect to calcium receptor activity, to diagnostic uses of these isoforms and to therapeutic uses of the agonists or antagonists. The invention also relates to gene therapy using the genes encoding the receptor isoforms or molecules capable of down-regulating receptor activity, such as antisense sequences.

L'invention concerne des isoformes de récepteur de calcium humain, et les gènes codant ces isoformes. L'invention concerne en outre des procédés relatifs au criblage d'agonistes ou d'antagonistes vis-à-vis desdites isoformes, en particulier en égard à l'activité réceptrice de calcium, et elle concerne aussi des utilisations de ces isoformes et des utilisations thérapeutiques relatives aux agonistes ou aux antagonistes considérés. L'invention concerne également une thérapie génique faisant appel aux gènes qui codent les isoformes de récepteur en question ou des molécules capables de réguler à la baisse l'activité réceptrice (par exemple, séquences antisens).

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