Isoindole-imide compounds, compositions, and uses thereof

Details Isoindole-imide compounds, compositions, and uses thereof Isoindole-imide compounds, compositions, and uses thereof

C - Chemistry, Metallurgy

07

D

C07D 401/04 (2006.01) A61K 31/44 (2006.01) A61K 31/445 (2006.01) A61K 31/495 (2006.01) A61P 29/00 (2006.01) A61P 35/00 (2006.01) A61P 37/00 (2006.01) C07D 401/14 (2006.01) C07D 405/14 (2006.01) C07D 407/14 (2006.01) C07D 409/14 (2006.01)

Patent

CA 2433021

The invention relates to isoindole-imide compounds and pharmaceutically acceptable salts, hydrates, solvates, clathrates, enantiomers, diastereomers, racemates, or mixtures of stereoisomers thereof, pharmaceutical compositions comprising these isoindole-imide compounds, and methods for reducing the level of cytokines and their precursors in mammals. In particular, the invention pertains to isoindole-imide compounds that are potents inhibitors of the production of the TNF-.alpha. in mammals. The isoindole-imides described herein are useful for treating or preventing diseases or disorders in mammals, for example, cancers, such as solid tumors and blood-born tumors; heart disease, such as congestive heart failure; osteoporosis; and genetic, inflammatory, allergic; and autoimmune diseases.

La présente invention concerne des composés isoindole-imides, ainsi que des sels pharmaceutiquement acceptables, des hydrates, des solvates, des clathrates, des énantiomères, des diastéreomerès, des racémates, ou des mélanges de stéréoisomères de ceux-ci, des compositions pharmaceutiques comprenant ces composés isoindole-imides, et des méthodes permettant de réduire le niveau des cytokines et de leurs précurseurs chez des mammifères. En particulier, la présente invention concerne des composés isoindole-imides qui sont des inhibiteurs puissants de la production du TNF-.alpha. chez des mammifères. Les isoindole-imides décrits dans cette invention sont utilisés pour le traitement ou la prévention de maladies ou de troubles chez des mammifères, par exemple, les cancers, tels que des tumeurs solides et des tumeurs à diffusion hématogène; une cardiopathie, telle qu'une insuffisance cardiaque congestive; l'ostéoporose; et les maladies génétiques, inflammatoires, allergiques et auto-immunes.

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