Isoindolin-1-one derivative and anti-arrhythmic agent

Details Isoindolin-1-one derivative and anti-arrhythmic agent Isoindolin-1-one derivative and anti-arrhythmic agent

C - Chemistry, Metallurgy

07

D

167/208, 260/321

C07D 209/46 (2006.01) A61K 31/40 (2006.01) C07D 209/48 (2006.01) C07D 401/04 (2006.01) C07D 403/06 (2006.01) C07D 491/10 (2006.01)

Patent

CA 1284647

ABSTRACT OF THE DISCLOSURE Isoindolin-1-one compounds represented by the following formula (I); Image (I) {wherein n represents an integer of 1 to 6; m represents 0 or 1; R1, R2 and R3 are each independently hydrogen or lower alkyl, and when m is 1, R1 and one of R2 and R3 may form a five-membered or six-membered ring over N atom; X represents hydrogen or hydroxy; Ar represents naphthyl, pyridyl or substituted phenyl represented by the formula (II); Ar and X may form a lactone ring; Image (II) [wherein Y represents carboxyl, lower alkoxycarbonyl, carbamoyl, N,N-lower alkyl-substituted carbamoyl or amino represented by the formula (III): Image (III) (wherein R6 and R7 are each independently hydrogen, lower alkyl or lower alkanoyl); R4 and R5 are each independently hydrogen, lower alkyl, cyano or halogen]} or a pharmaceutically acceptable acid addition salt or metal salt thereof have an excellent antiarrhythmic activity.

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