Isoindolinone and related analogs as sirtuin modulators

Details Isoindolinone and related analogs as sirtuin modulators Isoindolinone and related analogs as sirtuin modulators

C - Chemistry, Metallurgy

07

D

C07D 403/12 (2006.01) A61K 31/4035 (2006.01) A61K 31/427 (2006.01) A61K 31/437 (2006.01) A61K 31/443 (2006.01) A61K 31/4439 (2006.01) A61K 31/4523 (2006.01) A61K 31/498 (2006.01) A61K 31/4985 (2006.01) A61K 31/519 (2006.01) A61K 31/5377 (2006.01) A61P 1/00 (2006.01) A61P 3/04 (2006.01) A61P 3/06 (2006.01) A61P 3/10 (2006.01) A61P 5/14 (2006.01) A61P 5/38 (2006.01) A61P 5/50 (2006.01) A61P 7/02 (2006.01) A61P 7/06 (2006.01) A61P 9/00 (2006.01) A61P 9/10 (2006.01) A61P 11/00 (2006.01) A61P 11/06 (2006.01) A61

Patent

CA 2746221

Provided herein are novel sirtuin-modulating compounds and methods of use thereof. The sirtuin-modulating compounds may be used for increasing the lifespan of a cell, and treating and/or preventing a wide variety of diseases and disorders including, for example, diseases or disorders related to aging or stress, diabetes, obesity, neurodegenerative diseases, cardiovascular disease, blood clotting disorders, inflammation, cancer, and/or flushing as well as diseases or disorders that would benefit from increased mitochondrial activity. Also provided are compositions comprising a sirtuin- modulating compound in combination with another therapeutic agent.

L'invention porte sur de nouveaux composés modulant les sirtuines et sur leurs procédés d'utilisation. Les composés modulant les sirtuines peuvent être utilisés pour l'augmentation de la durée de vie d'une cellule et le traitement et/ou la prévention d'un grand nombre de maladies et de troubles dont, par exemple, des maladies ou des troubles liés au vieillissement ou au stress, le diabète, l'obésité, des maladies neurodégénératives, une maladie cardiovasculaire, des troubles de la coagulation du sang, une inflammation, un cancer et/ou des bouffées vasomotrices ainsi que des maladies ou des troubles qui tireraient avantage d'une activité mitochondriale accrue. L'invention porte également sur des compositions comprenant un composé modulant les sirtuines en association avec un autre agent thérapeutique.

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