C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 209/44 (2006.01) A61K 31/4035 (2006.01) A61K 31/437 (2006.01) A61K 31/4985 (2006.01) A61P 35/00 (2006.01) C07D 403/06 (2006.01) C07D 413/04 (2006.01) C07D 471/04 (2006.01) C07D 487/04 (2006.01)
Patent
CA 2727252
The invention relates to isoindolones of formula, (I) with anti-cancer and/or anti-inflammatory activity and more specifically with MEK kinase inhibitory activity. The invention provides compositions and methods useful for inhibiting abnormal cell growth, treating a hyperproliferative disorder, or treating an inflammatory disease in a mammal. The invention also relates to methods of using the compounds for in vitro, in situ, and in vivo diagnosis or treatment of mammalian cells, or associated pathological conditions.
La présente invention concerne des isoindolones de formule (I) ayant une activité anticancéreuse ou anti-inflammatoire et plus spécifiquement une activité d'inhibition de la MEK kinase. L'invention concerne des compositions et des procédés utiles pour l'inhibition d'une croissance cellulaire anormale, le traitement d'un trouble d'hyperprolifération, ou le traitement d'une maladie inflammatoire chez un mammifère. L'invention concerne également des procédés d'utilisation des composés pour le diagnostic ou le traitement in vitro, in situ et in vivo de cellules mammifères, ou de conditions pathologiques associées.
Gancia Emanuela
Heald Robert Andrew
Jackson Philip
Price Stephen
Genentech Inc.
Smart & Biggar
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