Isolated amphiphilic peptides derived from the cytoplasmic...

C - Chemistry – Metallurgy – 12 – N

Patent

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

C12N 15/48 (2006.01) A61K 38/16 (2006.01) A61K 48/00 (2006.01) C07K 14/15 (2006.01) C12N 5/10 (2006.01) C12N 7/01 (2006.01) C12N 15/86 (2006.01) C12N 15/867 (2006.01)

Patent

CA 2333855

An isolated peptide comprising an amino acid sequence derived from a viral envelope protein, wherein at least a portion of the amino acid sequence is located within the cytoplasmic tail or membrane-spanning region of a viral envelope protein. Such peptides are amphiphilic in nature, provide for the destabilization of membranes, and facilitate the entry of viral particles into cells and the efficient formation of viral particles. The peptides may, in another embodiment, be attached to the viral membrane, along with a targeting polypeptide, as part of an artificial viral envelope protein.

La présente invention concerne un peptide isolé comprenant une séquence d'acides aminés dérivée d'une protéine d'enveloppe virale. Une partie au moins de la séquence d'acides aminés est située à l'intérieur de la queue cytoplasmique ou de la région de recouvrement de membrane d'une protéine d'enveloppe virale. De tels peptides, qui sont de nature amphiphile, assurent une déstabilisation des membranes et favorisent, d'une part l'entrée de particules virales dans les cellules, et d'autre part la formation en bonne et due forme de particules virales. Selon une autre réalisation, ces peptides peuvent, associés à un polypeptide de ciblage, être liés à la membrane virale, constituant ainsi une partie d'une protéine artificielle de l'enveloppe virale.

LandOfFree

Say what you really think

Search LandOfFree.com for Canadian inventors and patents. Rate them and share your experience with other people.

Rating

Isolated amphiphilic peptides derived from the cytoplasmic... does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Isolated amphiphilic peptides derived from the cytoplasmic..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Isolated amphiphilic peptides derived from the cytoplasmic... will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFCA-PAI-O-1372715

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.