Isolated and purified human soluble guanylyl cyclase...

Details Isolated and purified human soluble guanylyl cyclase... Isolated and purified human soluble guanylyl cyclase...

C - Chemistry, Metallurgy

12

N

C12N 15/60 (2006.01) A61K 48/00 (2006.01) A61P 9/10 (2006.01) C07K 16/40 (2006.01) C12N 9/88 (2006.01) C12N 15/62 (2006.01) C12P 21/02 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2339529

The invention relates to the expression of the cDNA clone for sub-units a1 (hsGCa1) and b1 (hsGCb1) of human soluble guanylylcyclase and the subsequent purification of the active enzyme and use thereof, the medical application of the expression of this clone by gene transfer, in addition to antibodies against peptides derived from said sequence and the use thereof.

Expression du clone d'ADNc pour les sous-unités a1 (hsGCa1) et b1 (hsGCb1) de la guanylylcyclase humaine soluble, purification ultérieure de l'enzyme active et son utilisation, utilisation médicale de l'expression de ce clone par le transfert génique, ainsi qu'anticorps contre des peptides dérivés de la séquence et leur utilisation.

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