C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 16/18 (2006.01) C07K 14/47 (2006.01) C07K 16/28 (2006.01) G01N 33/53 (2006.01) G01N 33/577 (2006.01) G01N 33/68 (2006.01)
Patent
CA 2175451
Dense microspheres (DMS) present in the brain of individuals susceptible to cerebral amyloidosis disintegrate into DMS components to form cerebral amyloid plaques and other DMS components that are removed from the brain via circulating bodily fluids. Detecting the presence of these removed DMS components in circulating bodily fluids provides a diagnostic mechanism to determine the onset of cerebral amyloid plaque formation. Antibodies also can be raised against isolated DMS components and subsequently utilized in a diagnostic method capable of detecting the onset of cerebral amyloid plaque formation.
Les microsphères denses présentes dans le cerveau d'individus sujets à l'amyloïdose cérébrale se désintègrent en composants de microsphères pour former des plaques d'amyloïde cérébrale et d'autres composants de microsphères denses qui sont évacués du cerveau par des liquides biologiques en circulation. La détection de la présence de composants de microsphères denses dans les liquides biologiques en circulation permet de diagnostiquer un début de formation de plaques d'amyloïde cérébrale. On peut également diriger des anticorps contre les composants de microsphères denses isolés et les utiliser dans une technique diagnostique permettant de détecter un début de formation de plaques d'amyloïde cérébrale.
Norton Rose Or S.e.n.c.r.l. S.r.l./llp
Nymox Corporation
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