Isolated human drug-metabolizing proteins, nucleic acid...

C - Chemistry – Metallurgy – 12 – N

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C12N 9/10 (2006.01) C12N 15/00 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2420696

The present invention provides amino acid sequences of peptides that are encoded by genes within the human genome, the drug-metabolizing enzyme peptides of the present invention. The present invention specifically provides isolated peptide and nucleic acid molecules, methods of identifying orthologs and paralogs of the drug-metabolizing enzyme peptides, and methods of identifying modulators of the drug-metabolizing enzyme peptides.

L'invention concerne des séquences d'acides aminés de peptides codés par des gènes dans le génome humain, ci-après dénommés peptides enzymatiques de métabolisation de médicaments. L'invention concerne notamment un peptide isolé et des molécules d'acides nucléiques, des procédés d'identification d'orthologues et de paralogues des peptides enzymatiques de métabolisation de médicaments, ainsi que des procédés d'identification de modulateurs des peptides enzymatiques de métabolisation de médicaments.

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