C - Chemistry – Metallurgy – 07 – C
Patent
C - Chemistry, Metallurgy
07
C
C07C 215/64 (2006.01) A61K 31/095 (2006.01) A61K 31/135 (2006.01) A61K 31/351 (2006.01) C07C 291/02 (2006.01) C07C 305/20 (2006.01) C07C 305/24 (2006.01)
Patent
CA 2666350
The present invention provides novel isolated compounds characterized as metabolites or derivatives of desmethylvenlafaxine including hydroxy-DV metabolites, hydroxy-DV-glucuronide metabolites, N-oxide-DV metabolites, and benzyl-hydroxy-DV metabolites. The invention includes pharmaceutical compositions comprising any of the metabolites or derivatives of the invention in combination with a pharmaceutically acceptable carrier or excipient. The invention also includes a method of treating at least one central nervous system disorder in a mammal comprising providing to a mammal in need thereof an effective amount of the compounds of the invention.
La présente invention concerne de nouveaux composés isolés caractérisés comme métabolites ou dérivés de desméthylvenlafaxine comprenant des métabolites hydroxy-DV, des métabolites hydroxy-DV-glucuronide, des métabolites N-oxyde-DV et des métabolites benzyl-hydroxy-DV. L'invention concerne des compositions pharmaceutiques comprenant l'un quelconque des métabolites et dérivés de l'invention en combinaison avec un support ou un excipient pharmaceutique acceptable. L'invention concerne également un procédé de traitement d'au moins un trouble du système nerveux central chez un mammifère consistant à administrer audit mammifère une quantité efficace des composés de la présente invention. DRAWING: FIG.1a: NOVEL ISOLATED COMPOUNDS CHARACTERIZED AS METABOLITES OF DVS NOUVEAUX COMPOSES ISOLES CARACTERISES COMME METABOLITES DE DVS
Demaio William
Hoffmann Matthew John
Ullrich John William
Wang Jim
Torys Llp
Wyeth
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