Isolated metallopolypeptide: compositions and synthetic methods

Details Isolated metallopolypeptide: compositions and synthetic methods Isolated metallopolypeptide: compositions and synthetic methods

C - Chemistry, Metallurgy

12

N

C12N 9/00 (2006.01) C07K 7/08 (2006.01)

Patent

CA 2093214

2093214 9206110 PCTABS00011 This invention contemplates an isolated metallopolypeptide comprising a polyvalent metal ion coordinately linked to 2 to about 8 polypeptide binding ligands, wherein at least 2 of said polypeptide binding ligands are covalently bonded to a linear amphiphilic peptide. The linear amphiphilic peptide has an alpha-helix, beta-sheet or beta-turn conformation. This invention further contemplates a metal ion-assisted, self-assembly method for producing a metallopolypeptide.

L'invention se rapporte à un métallopolypeptide isolé comprenant un ion métallique polyvalent coordonné à des ligands polypeptides situés entre 2 et 8 environ, où au moins 2 desdits ligands polypeptides sont en liaison covalente avec un peptide linéaire amphiphile. Le peptide linéaire amphiphile possède une structure en hélice alpha, feuillet bêta ou spire bêta. L'invention se rapporte, de plus, à un procédé d'auto-assemblage, à l'aide d'un ion métallique, servant à produire un métallopolypeptide.

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