Isolated molecules comprising epitopes containing sulfated...

C - Chemistry – Metallurgy – 12 – N

Patent

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Details

C12N 15/12 (2006.01) A61K 38/04 (2006.01) A61K 38/17 (2006.01) A61K 39/395 (2006.01) A61K 45/06 (2006.01) A61K 47/48 (2006.01) C07K 5/04 (2006.01) C07K 7/04 (2006.01) C07K 14/435 (2006.01) C07K 14/47 (2006.01) C07K 16/30 (2006.01) C07K 16/46 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2433225

The present invention provides epitopes present on cancer cells and important in physiological phenomena such as cell rolling, metastasis, and inflammation. Therapeutic and diagnostic methods and compositions using antibodies capable of binding to the epitopes are provided. Methods and compositions according to the present invention can be used in diagnosis of and therapy for such diseases as cancer, including tumor growth and metastasis, leukemia, auto- immune disease, and inflammatory disease.

L'invention concerne des épitopes propres aux cellules cancéreuses, qui jouent un rôle important dans certains phénomènes physiologiques comme le roulement cellulaire, la métastase et l'inflammation. L'invention concerne également des procédés et des compositions thérapeutiques et diagnostiques faisant intervenir des anticorps capables de se lier avec les épitopes. Les procédés et les compositions en question peuvent s'appliquer au diagnostic et à la thérapie pour une série de maladies, à savoir par exemple: cancer, y compris la croissance tumorale et la métastase, leucémie, maladie auto-immune, et maladie inflammatoire.

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