C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/12 (2006.01) A61K 39/385 (2006.01) C07K 7/06 (2006.01) C07K 14/47 (2006.01) C07K 14/705 (2006.01) C07K 16/30 (2006.01) C07K 17/00 (2006.01) C12N 5/10 (2006.01) C12Q 1/02 (2006.01) C12Q 1/18 (2006.01) G01N 33/566 (2006.01) G01N 33/574 (2006.01) A61K 38/00 (2006.01) A61K 39/00 (2006.01)
Patent
CA 2143335
The invention involves a nonapeptide derived from the tumor rejection antigen precursor encoded by gene MAGE-3. This nonapeptide is presented by HLA molecules HLA-A1. The resulting complexes are identified by cytolytic T cells. Such recognition may be used in diagnostics, or therapeutically.
L'invention se rapporte à un nonapeptide dérivé du précurseur de l'antigène de rejet tumoral codé par le gène MAGE-3. Ce nonapeptide est présenté par les molécules HLA-A1. Les complexes obtenus sont identifiés par les lymphocytes T cytolytiques. Cette reconnaissance peut être utilisée dans les diagnostics ou les thérapies.
Boon-Falleur Thierry
de Plaen Etienne
Lurquin Christophe
Traversari Catia
Van Der Bruggen Pierre
Ludwig Institute For Cancer Research
Norton Rose Or S.e.n.c.r.l. S.r.l./llp
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