Isolated nonapeptide derived from mage-3 gene and presented...

C - Chemistry – Metallurgy – 12 – N

Patent

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Details

C12N 15/12 (2006.01) A61K 39/385 (2006.01) C07K 7/06 (2006.01) C07K 14/47 (2006.01) C07K 14/705 (2006.01) C07K 16/30 (2006.01) C07K 17/00 (2006.01) C12N 5/10 (2006.01) C12Q 1/02 (2006.01) C12Q 1/18 (2006.01) G01N 33/566 (2006.01) G01N 33/574 (2006.01) A61K 38/00 (2006.01) A61K 39/00 (2006.01)

Patent

CA 2143335

The invention involves a nonapeptide derived from the tumor rejection antigen precursor encoded by gene MAGE-3. This nonapeptide is presented by HLA molecules HLA-A1. The resulting complexes are identified by cytolytic T cells. Such recognition may be used in diagnostics, or therapeutically.

L'invention se rapporte à un nonapeptide dérivé du précurseur de l'antigène de rejet tumoral codé par le gène MAGE-3. Ce nonapeptide est présenté par les molécules HLA-A1. Les complexes obtenus sont identifiés par les lymphocytes T cytolytiques. Cette reconnaissance peut être utilisée dans les diagnostics ou les thérapies.

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