Isolated nucleic acid molecule which codes for a tumor...

C - Chemistry – Metallurgy – 12 – N

Patent

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C12N 15/12 (2006.01) A61K 35/14 (2006.01) A61K 39/00 (2006.01) C07K 7/06 (2006.01) C07K 14/47 (2006.01) C07K 14/705 (2006.01) C07K 14/74 (2006.01) C12N 5/08 (2006.01) C12Q 1/68 (2006.01) G01N 33/569 (2006.01)

Patent

CA 2191728

A nucleic acid molecule which codes for a tumor antigen precursor which is in turn processed to antigens presented by an HLA molecule is described. The HLA molecule may be HLA-A2, HLA-A28, HLA-B13, HLA-B44 or HLA-Cw6. The antigens are also described. These materials are useful in diagnostic and therapeutic methodologies. The tumor rejection antigen precursor is not tyrosinase, which has been previously identified as a tumor rejection antigen precursor processed to an antigen presented by HLA-B44. The figure sets forth data regarding cytolytic activity of lymphocytes obtained in autologous mixed lymphocyte-tumor cell cultures.

Molécule d'acide nucléique codant pour un précurseur d'antigène de tumeur, qui est, à son tour, traité, afin d'obtenir des antigènes présentés par une molécule HLA. La molécule HLA peut être HLA-A2, HLA-A28, HLA-B13, HLA-B44 ou HLA-Cw6. L'invention concerne également les antigènes. Ces matériaux s'utilisent efficacement dans des méthodologies diagnostiques et thérapeutiques. Le précurseur d'antigène de rejet de tumeur n'est pas tyronase, identifié précédemment en tant que précurseur d'antigène de rejet de tumeur traité, afin d'obtenir un antigène présenté par HLA-B44. La figure illustre des données concernant l'activité cytolytique de lymphocytes obtenus dans des cultures autologues mixtes de lymphocytes/cellules cancéreuses.

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