C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/11 (2006.01) A61K 31/7105 (2006.01) A61P 35/00 (2006.01) C12Q 1/68 (2006.01) A61K 48/00 (2006.01) C07H 21/04 (2006.01)
Patent
CA 2683314
Provided herein are isolated nucleic acid molecule corresponding to miR145 that are useful in treating colon cancer. The disclosed miR145 nucleic acids specifically bind the 3' UTR within endogenous IRS-I such as to suppress or inhibit colon cell proliferation.
La présente invention concerne des molécules d'acide nucléique isolées correspondant à miR145 qui sont utiles dans le traitement du cancer du côlon. Ces acides nucléiques miR145 se lient spécifiquement au 3' UTR de IRS-I endogène de manière à supprimer ou à inhiber la prolifération des cellules du côlon.
Baserga Renato
Linsley Peter
Sepp-Lorenzino Laura
Shi Bin
Gowling Lafleur Henderson Llp
Merck & Co. Inc.
Merck Sharp & Dohme Corp.
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