C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/54 (2006.01) A61K 38/45 (2006.01) C07K 16/40 (2006.01) C12N 1/20 (2006.01) C12N 5/00 (2006.01) C12N 9/12 (2006.01) C12Q 1/02 (2006.01) C12Q 1/48 (2006.01) C12Q 1/68 (2006.01) G01N 33/53 (2006.01)
Patent
CA 2438978
Disclosed herein are two newly identified enzymes - mitogen-activated protein kinase-activated protein kinase-2, each comprising a sequence of nucleotides as set forth in SEQ ID NOs: 1 and 3. Each of the herein disclosed enzymes is a serine/threonine signal transduction kinase that is phosphorylated and activated by Erks and p38 MAPK in vitro. Also disclosed, inter alia, are cells containing the recombinant nucleic acid molecules; antisense constructs thereto; antibodies specific for each of the disclosed proteins; methods for using the novel nucleic acid molecules and their gene products including kits containing the same.
Cette invention concerne deux enzymes récemment identifiés protéine kinase activée par mitogène et protéine kinase-2 activée, comprenant chacun une séquence de nucléotides comme représenté dans SEQ ID NO: 1 et 3. Chacune des enzymes couvertes par l'invention est une sérine-thréonine kinase de transduction de signal qui est phosphorylée et activée par Erks et p38 MAPK in vitro. L'invention concerne également, inter alia, des cellules renfermant les molécules d'acides nucléiques de recombinaison, des constuctions antisens et des anticorps spécifiques pour chacune des protéines de l'invention. Sont également décrites des méthodes d'utilisation des nouvelles molécules d'acides nucléiques et de leurs produits géniques, dont des kits les renfermant.
Hawkins Julio
Lisnock Jean Marie
Lograsso Philip
Merck & Co. Inc.
Ogilvy Renault Llp/s.e.n.c.r.l.,s.r.l.
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