Isolated nucleic acid molecules which encode t cell...

Details Isolated nucleic acid molecules which encode t cell... Isolated nucleic acid molecules which encode t cell...

C - Chemistry, Metallurgy

12

N

C12N 15/24 (2006.01) C07K 14/54 (2006.01) C12N 15/63 (2006.01) G01N 33/50 (2006.01) G01N 33/68 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2416820

The invention involves isolation of nucleic acid molecules, the expression of which are upregulated by interleukin-9. The amino acid sequences of the proteins which correspond to the nucleic acid molecules show some structural features of cytokines. In addition to the nucleic acid molecules and the proteins, various uses of the molecules are disclosed. The molecules are referred to as T cell inducible factors. The molecules are implicated in activation of STAT molecules, acute phase proteins, and inflammation.

L'invention concerne l'isolation de molécules d'acide nucléique, dont l'expression est régulée de manière positive par l'interleukine-9. Les séquences d'acide aminé des protéines correspondant aux molécules d'acide nucléique mettent en évidence certaines caractéristiques structurelles des cytokines. L'invention concerne également différentes utilisations de ces molécules. Les molécules sont désignées comme des facteurs inductibles dérivés de lymphocytes T. Ces molécules interviennent dans l'activation de molécules STAT, de protéines de phase aiguë, et d'inflammation.

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