Isolated organ perfusion combination therapy of cancer

Details Isolated organ perfusion combination therapy of cancer Isolated organ perfusion combination therapy of cancer

A - Human Necessities

61

K

A61K 38/17 (2006.01) A61P 35/00 (2006.01)

Patent

CA 2637540

The invention relates to a combination therapy for the treatment of tumors and tumor metastases comprising administration of integrin ligands, preferably integrin antagonists, together with co-therapeutic agents or therapy forms that have synergistic efficacy when administered together with said ligands, such as chemotherapeutic agents and/or radiation therapy, in isolated organ perfusion. The therapy results in a synergistic potential increase of the inhibition effect of each individual therapeutic on tumor cell proliferation, yielding more effective treatment than found by administering an individual component alone.

L'invention concerne une thérapie combinée pour le traitement de tumeurs et de métastases tumorales, comprenant l'administration de ligands des intégrines, de préférence d'antagonistes des intégrines, en combinaison avec des agents thérapeutiques ou des formes de thérapie associé(e)s qui possèdent une efficacité synergique lorsqu'ils sont administrés conjointement avec lesdits ligands, par exemple des agents chimiothérapeutiques et/ou un radiothérapie, dans la perfusion d'organes isolés. Cette thérapie se traduit par une augmentation du potentiel synergique de l'effet inhibiteur de chaque système thérapeutique individuel sur la prolifération des cellules tumorales, et donc par un traitement plus efficace que l'administration d'un composant individuel seul.

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