C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/18 (2006.01) A61K 38/18 (2006.01) C07K 14/475 (2006.01) C12N 1/21 (2006.01) C12N 15/12 (2006.01)
Patent
CA 2465714
The invention concerns a peptide substance selected from the group consisting of: (i) peptide N derived from the HGF .alpha. chain and having an amino acid sequence represented by SEQ ID No. 2, and (ii) its peptide variants derived from said peptide N sequence by suppression, substitution or addition of one or several amino acids. Said peptide N has an anti-angiogenic activity in accordance with a mechanism different from competitive fixation with HGF on the HGF-R receptor. The invention also concerns the therapeutic use and the preparation method of said peptide substance, as well as (i) the DNA fragment which expresses it, the plasmid containing said DNA and the bacteria containing said plasmid.
La présente invention concerne une substance peptidique choisie parmi l'ensemble constitué par: (i) le peptide N issu de la chaîne .alpha. de HGF et ayant la séquence aminoacide représentée par SEQ ID No.: 2, et (ii) ses variants peptidiques dérivant de la séquence dudit peptide N par suppression, substitution ou addition d'un ou plusieurs aminoacides, ledit peptide N et ses variants ayant une activité antiangiogénique selon un mécanisme différent de la fixation compétitive avec HGF sur le récepteur HGF-R. Elle concerne également l'utilisation thérapeutique et le procédé de préparation de ladite substance peptidique, ainsi que (i) le fragment de DNA qui l'exprime, le plasmide contenant ledit DNA et la bactérie contenant ledit plasmide.
Institut Des Vaisseaux Et Du Sang
Norton Rose Or S.e.n.c.r.l. S.r.l./llp
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