C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 14/745 (2006.01) A61K 38/36 (2006.01) C07K 1/14 (2006.01) A61K 38/00 (2006.01)
Patent
CA 2042399
71 Abstract of the Disclosure Disclosed is an isolated polypeptide (type II polypeptide) comprising a physiologically active human thrombomodulin polypeptide which has the activity of promoting the thrombin-catalyzed activation of protein C and which has a sugar chain comprising chondroitin and/or chondroitin sulfate attached to the peptide chain of the polypeptide. The type II polypeptide of the present invention can be obtained in an isolated form from a conventional culture containing an expres- sion product of the human thrombomodulin polypeptide gene which culture has been obtained by, for example, recombinant DNA techniques. The type II polypeptide of the present invention has excellent anticoagulant, platelet aggregation inhibiting and thrombolytic activ- ities.
Gomi Komakazu
Ogawa Kohei
Yamamoto Shuji
Asahi Kasei Kogyo Kabushiki Kaisha
Gomi Komakazu
Goudreau Gage Dubuc
Ogawa Kohei
Yamamoto Shuji
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