Isolated polynucleotides having a reduced or an increased...

Details Isolated polynucleotides having a reduced or an increased... Isolated polynucleotides having a reduced or an increased...

C - Chemistry, Metallurgy

12

N

C12N 15/67 (2006.01) A61K 31/713 (2006.01) C12N 1/19 (2006.01) C12N 5/10 (2006.01) C12N 9/38 (2006.01) C12N 15/11 (2006.01) C12N 15/56 (2006.01) C12Q 1/68 (2006.01)

Patent

CA 2394142

The present invention is concerned with modified polynucleotides derived from a native gene and having a reduced or increased number of epigenetic control motifs, at the nucleotide level, as compared to the native gene. These polynucleotides are useful to study, increase and/or reduce genes expression, and to improve DNA vaccination methods. The present invention also relates to methods of using these modified polynucleotides in in vitro andin vivo expression systems.

Cette invention a trait à des polynucléotides modifiés dérivés d'un gène endogène et possédant une teneur en motifs de régulation épigénétiques, au niveau nucléotidique, réduite ou renforcée par rapport au gène endogène. Ces polynucléotides se révèlent utiles pour l'investigation, l'augmentation et/ou la réduction de l'expression des gènes ainsi que pour l'amélioration de méthodes de vaccination par ADN. Cette invention porte également sur des méthodes d'utilisation de ces polynucléotides dans des systèmes d'expression in vitro et in vivo.

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