Isolated polysialyl transferases, nucleic acid molecules...

C - Chemistry – Metallurgy – 12 – N

Patent

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C12N 15/54 (2006.01) A61K 31/70 (2006.01) A61K 48/00 (2006.01) C07H 21/00 (2006.01) C07K 14/31 (2006.01) C07K 16/40 (2006.01) C07K 19/00 (2006.01) C12N 9/10 (2006.01) C12N 15/27 (2006.01) C12N 15/31 (2006.01) C12N 15/62 (2006.01) C12P 19/18 (2006.01) C12P 21/00 (2006.01) C12Q 1/68 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2208291

Isolated nucleic acid molecules encoding polysialyl transferases, and the polysialyl transferases themselves are disclosed. SEQ ID NOS: 1, 2, 7 and 8 present examples of these. The nucleic acid molecules and the proteins can be used diagnostically or therapeutically. Additionally, antisense oligonucleotides and antibodies are described, which can also be used diagnostically or therapeutically.

Sont présentées des molécules d'acide nucléique isolées codant des polysialyltransférases ainsi que les polysialyltransférases proprement dites. Les séquences nucléotidiques N?os¿ 1, 2, 7 et 8 en constituent des exemples. Les molécules d'acide nucléique et les protéines peuvent être utilisées dans un cadre diagnostique ou thérapeutique. Sont également présentés des oligonucléotides antisens et des anticorps pouvant aussi être utilisés dans un cadre diagnostique ou thérapeutique.

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