C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 9/78 (2006.01) C12P 7/40 (2006.01)
Patent
CA 2405515
Recombinant microbial strains are provided that express nitrilase enzyme and are useful as biocatalysts for the hydrolysis of nitrile-containing substrates. The recombinant cells are transformed with a foreign gene isolated from Acidovorax facilis 72W encoding a thermostable nitrilase enzyme that catalyzes the hydrolysis of nitrile-containing substrates to carboxylic acids under mild reaction conditions. The nucleotide sequence of the nitrilase gene and the deduced amino acid sequence encoded by the nitrilase gene are provided.
Cette invention concerne des souches microbiennes recombinantes qui expriment une enzyme nitrilase et qui conviennent bien comme biocatalyseurs pour l'hydrolyse de substrats renfermant des nitriles. Les cellules recombinantes sont transformées au moyen d'un gène étranger isolé de Acidovorax facilis 72W codant pour une enzyme nitrilase thermostable qui, en conditions de réaction douces, catalyse l'hydrolyse, en acides carboxyliques, de substrats renfermant des nitriles. L'invention porte sur la séquence nucléotidique du gène de nitrilase et la séquence d'acides aminés qui en est résulte et qui est codée par ledit gène.
Chauhan Sarita
Dicosimo Robert
Fallon Robert D.
Gavagan John E.
Payne Mark S.
Bennett Jones Llp
E.i. Du Pont de Nemours And Company
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