Isolation and structural elucidation of the cytostatic...

Details Isolation and structural elucidation of the cytostatic... Isolation and structural elucidation of the cytostatic...

C - Chemistry, Metallurgy

07

K

530/11, 167/103.

C07K 11/00 (2006.01) A61K 38/15 (2006.01)

Patent

CA 2012480

A new cytostatic depsipeptide, designated "dolastatin 15", was isolated from the Indian Ocean shell-like mollusk Dolabella auricularia. Dolastatin 15 inhibited growth of the PS leukemia with ED50 0.0024 µg/mL. Pharmaceutical preparations and therapeutic regimens utilizing Dolastatin 15, its synthetic counterpart and pharmaceutically active derivatives are disclosed. Dolastatin 15 has the structural formula: (see above formula)

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