Isolation and structural elucidation of the cytostatic...

Details Isolation and structural elucidation of the cytostatic... Isolation and structural elucidation of the cytostatic...

A - Human Necessities

61

K

167/103.8

A61K 38/15 (2006.01) C07K 11/02 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2013766

Abstract: The Indian Ocean sea hare Dolabella auricularia has been found to contain a new cell growth inhibitory and antineoplastic (P388 leukemia) cyclodepsipeptide designated dolastatin 13 and a companion substance dehydrodolastatin 13. A series of high field (400 MHz) 2D-NMR experiments including sequential analyses by HMBC and NOE techniques and tandem mass spectrometry provided structural determinations. Dolastatin 13 and dehydrodolastatin 13 represent a new class of cyclodepsipeptides. Pharmaceutical preparations and therapeutic regimens employing these new cytostatic depsipeptides are disclosed. The depsipeptides have the following structure: Image I:R1=OH;R2=H 2:R1,=R2=.DELTA.14.15

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