C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 11/02 (2006.01) A61K 38/15 (2006.01) C07K 11/00 (2006.01) C12P 21/04 (2006.01) A61K 38/00 (2006.01)
Patent
CA 2029678
A new cytostatic depsipeptide, designated "dolastatin 14", was isolated from the Indian Ocean shell-less mollusk Dolabella auricularia. Dolastatin 14 inhibited growth of the PS leukemia with ED50 0.0018 g/mL. Pharmaceutical preparations and therapeutic regimens utilizing Dolastatin 14, its synthetic counterpart and pharmaceutically active derivatives are disclosed. Dolastatin 14 has the structural formula: (see formula I)
Herald Cherry L.
Kamano Yoshiaki
Pettit George R.
Acti State University Arizona Board Of Regents A. Body Corporate Of The State Of Arizo
Acting On Behalf Of Arizona State University Arizona Board Of Regents A. Body Corporate
Borden Ladner Gervais Llp
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