A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 38/12 (2006.01) C07K 5/00 (2006.01) C07K 5/06 (2006.01) C07K 7/00 (2006.01) C07K 11/00 (2006.01) C07K 16/00 (2006.01) C07K 17/00 (2006.01) A61K 38/00 (2006.01)
Patent
CA 2282504
Cytostatic linear and cyclo-depsipeptides, "Dolastatin 16", "Dolastatin 18", and "Dolastatin 17", are disclosed which are obtained from Indian Ocean shellless mollusk Dolabella auricularia. Methods of using the substances to inhibit malignant cell growth associated with neoplastic diseases in animals and humans are also disclosed, as well as pharmaceutical preparations containing Dolastatin 16, Dolastatin 17, and Dolastatin 18.
L'invention concerne des depsipeptides cytostatiques linéaires et des cyclo-depsipeptides cytostatiques - la "dolastatine 16", la "dolastatine 18", la "dolastatine 17" - qui sont extraits d'un mollusque sans coquille de l'Océan indien, la dolabella auricularia. L'invention concerne également, d'une part, des procédés d'utilisation de ces substances en vue d'empêcher la croissance cellulaire maligne associée aux maladies néoplasiques chez les animaux et les humains et, d'autre part, des préparations pharmaceutiques contenant de la dolastatine 16, de la dolastatine 18 et de la dolastatine 17.
Pettit G.r.
Xu Jun-Ping
Arizona Board Of Regents
Cassan Maclean
LandOfFree
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