Isolation and structural elucidation of the human cancer...

Details Isolation and structural elucidation of the human cancer... Isolation and structural elucidation of the human cancer...

C - Chemistry, Metallurgy

07

H

C07H 15/00 (2006.01) A01N 43/04 (2006.01) C07H 15/04 (2006.01)

Patent

CA 2321542

A human cancer cell line bioassay-directed investigation of the Western Pacific marine sponge agelas sp. led to isolation of a trace (7.42 x 10-6% yield) cancer cell growth inhibitor (lung NCI-H460 GI50 0.77 µg/ml to ovary OVCAR-3 GI50 2.8 µg/ml) designated agelagalastatin (6). Agelagalastatin is the first example of a natural product containing a digalactofuranosyl unit.

Une étude sur l'éponge marine du Pacifique occidental Agelas sp. liée à des essais biologiques sur une lignée de cellules cancéreuses humaines a conduit à l'isolement d'une trace (7,42 x 10<-6> % de rendement) d'un inhibiteur de la croissance de cellules cancéreuses (0,77 mu g/ml NCI-H460 GI50 poumon à 2,8 mu g/ml OVCAR-3 GI50 ovaire) appelé agélagalastatine (6). L'agélagalastatine consitue le premier exemple de produit naturel contenant une unité de digalactofuranosyle.

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