Isolation and structure of dictyostatin 1

Details Isolation and structure of dictyostatin 1 Isolation and structure of dictyostatin 1

C - Chemistry, Metallurgy

07

D

C07D 313/00 (2006.01)

Patent

CA 2146880

ABSTRACT OF THE DISCLOSURE A new-type of macrocyclic lactone denominated "dictyostatin 1" bearing a 22-membered ring system is isolated from a Republic of Maldives marine sponge in the genus Spongia sp. and found to strongly inhibit the growth of an important selection of U.S. National Cancer Institute human cancer cell system and the murine P388 lymphocytic leukemia (PS ED50 3.8 x 10-4 mg/ml). Dictyostatin 1 has the following structure: Image 24

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