Isolation and structure of spongistatin 2, spongistatin 3,...

C - Chemistry – Metallurgy – 07 – H

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C07H 19/01 (2006.01) A61K 31/70 (2006.01) C07D 493/22 (2006.01)

Patent

CA 2126911

A black Spongia sp, in the Porifera class Demospongiae has been found to contain two new and exceptionally active cell (human cancers growth inhibitors,named spongistatin 2 and spongistatin 3. A bright colored Southwest Indian Ocean sponge Spirastrella spinispirulifera has also been found to contain related human cancer cell growth inhibitors named spongistatin 4 and spongistatin 6. A method of treating human cancer cells with spongistatin 1, spongistatin 2, spongistatin 3, spongistatin 4 and spongistatin 6 is also disclosed. The approximate mean GI50 of the disclosed compounds in the NCI cell line panel is about 10-10µg/ml. 59

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