C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/54 (2006.01) C07K 16/40 (2006.01) C12N 9/12 (2006.01) C12N 15/11 (2006.01) C12Q 1/48 (2006.01) G01N 33/50 (2006.01) G01N 33/573 (2006.01) A61K 38/00 (2006.01)
Patent
CA 2416800
Isolated nucleic acid molecules comprising polynucleotide having sequences that encode human and Drosophila PAR-1 kinases. Also provided are proteins and polypeptides encoded by the nucleic acid molecules, methods of modulating PAR- 1 expression and function, and methods of modulating the Wnt signaling pathway.
La présente invention concerne des molécules d'acides nucléiques isolées contenant des polynucléotides présentant des séquences qui codent des PAR-1 kinases humaines et d'origine drosophile. Par ailleurs, l'invention concerne des protéines et des polypeptides codés par les molécules d'acides nucléiques, des méthodes de modulation de l'expression et de la fonction PAR-1, ainsi que des méthodes de modulation du processus de signalisation Wnt.
Fantl Wendy J.
Feng Jia-Jia
Reinhard Christoph
Sun Tian-Qiang
Williams Lewis T.
Borden Ladner Gervais Llp
Chiron Corporation
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