Isolation of muscle-derived stem cells and uses therefor

Details Isolation of muscle-derived stem cells and uses therefor Isolation of muscle-derived stem cells and uses therefor

C - Chemistry, Metallurgy

12

N

C12N 5/06 (2006.01) A61K 35/32 (2006.01) A61K 48/00 (2006.01) A61P 21/00 (2006.01) A61P 35/00 (2006.01) C12N 5/08 (2006.01) C12N 5/10 (2006.01) A61K 35/12 (2006.01)

Patent

CA 2386559

A method for purifying muscle stem cells from a myoblast sample isolated from mammalian skeletal muscle is disclosed. Purified muscle stem cells can be used for a variety of purposes, including for systemic delivery of muscle proteins and other desired nucleic acid products to a mammal, for gene therapy, in the treatment muscle diseases, including muscular dystrophies, in the treatment or prophylaxis of inherited or acquired diseases, including genetic diseases and cancer, and in transplanting bone marrow to a mammal.

L'invention concerne une méthode de purification de cellules souches musculaires issues d'un échantillon de myoblaste isolé du muscle squelettique mammalien. Des cellules souches musculaires purifiées peuvent être utilisées à des fins diverses, notamment pour la distribution systémique de protéines musculaires et d'autres produits acides voulus à un mammifère, pour effectuer une thérapie génique, dans le traitement des maladies musculaires, notamment les dystrophies musculaires, dans le traitement ou la prévention des maladies héréditaires ou acquises, notamment les maladies génétiques et le cancer et pour la transplantation de moelle osseuse à un mammifère.

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