Isolation of pancreatin

Details Isolation of pancreatin Isolation of pancreatin

A - Human Necessities

61

K

195/37, 167/103.

A61K 35/39 (2006.01) C12N 9/94 (2006.01)

Patent

CA 1208580

- 18 - Abstract of the Disclosure: Highly active pancreatin is obtained by autolysis of an aqueous isopropanol-containing tissue slurry, preferably buffered with sodium bicarbon- ate, until a test precipitation with aqueous isopropyl alcohol proves positive, and precipitating the batch with a higher concentration of isopropyl alcohol, resulting in a fiber suspension which can be sieved so that the solu- tion obtained permits direct isolation of pancreatin by further increasing the concentration of isopropyl alco- hol. A high bulk density of the finished dry prepara- tion is achieved by stirring the precipitated pancreatin with isopropyl alcohol or acetone so as to bring the pan- creatin to a concentration of 70 - 85% of isopropanol or 80 - 95% of acetone, isolating the pancreatin by suctior filtration or centrifuging and drying it by treatment with dry air or nitrogen.

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