C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
195/33.1, 167/10
C12N 9/72 (2006.01) A61K 38/00 (2006.01)
Patent
CA 1164341
Abstract The existence of high fibrin-affinity uroki- nase is discovered by an isolation procedure using fibrin precipitated on an adsorptive-solid matrix. By the method described, the high affinity form of plasminogen activator can be isolated directly from urine or from kidney tissue culture medium. The method is economical and provides a relatively high yeild of the activator. The high affinity that this plasminogen activator has for fibrin is a property that makes it an improved thrombolytic agent and when radiolabelled provides a new diagnostic agent for the specific detection of fibrin thrombi through nuclear scanning. The newly-isolated plasminogen activator has the following characteristics: a molecular weight of about 56,000 Daltons, a specific activity of about 40,000 - 50,000 CTA units/mg, the appearance of a single chain structure and a high affinity for fibrin.
364452
Gurewich Victor
Husain Syed S.
Lipinski Boguslaw
Gurewich Victor
Husain Syed S.
Lipinski Boguslaw
Smart & Biggar
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