G - Physics – 01 – N
Patent
G - Physics
01
N
167/37
G01N 33/564 (2006.01) G01N 33/569 (2006.01)
Patent
CA 1247005
Abstract of the Disclosure This invention relates to the production of core antigens of the virus HTLV-III and their use in detection of antibodies in sera of AIDS and pre-AIDS patients, and to biochemical and immunological analysis of antigens associated with the virus HTLV-III. The utilization of p24 and p41 core antigens enables a greater specificity of detection. It is shown that antigens associated with the infection of human cells by the virus are specifi- cally recognized by antibodies from AIDS patients Specifically, HTLV-III isolated from AIDS patients and transformed by cocultivation with an HT cell line is specifically detected by antibodies from human sera taken from AIDS patients. The p24 and p41 antigens are used to monitor the presence of HTLV-III in cultured cells and cell-free culture fluids, where virus infection is sus- pected, and also to monitor antibodies in human sera. The method of detection of antibodies preferred is a radioimmunoassay (RIA), ELISA (an enzyme-linked immuno- sorbent assay) or indirect immunofluoresceence assay.
479703
Gallo Robert C.
Popovic Mikulas
Sarngadharan Mangalasseril G.
Gowling Lafleur Henderson Llp
Litton Bionetics Inc.
U.s. Departm Ent Of Commerce The United States Of America Represented By The Secretary
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