Isolation of the laminin .gamma.2 gene in horses and its use...

C - Chemistry – Metallurgy – 12 – N

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C12N 15/12 (2006.01) C07H 21/00 (2006.01) C07K 14/78 (2006.01) C07K 16/18 (2006.01) C12N 15/11 (2006.01) C12Q 1/68 (2006.01)

Patent

CA 2417299

The laminin .gamma.2 subunit of equine laminin-5 gene has been cloned and the nucleic acid and corresponding protein amino acid sequence is provided. A method of diagnosing junctional epidermolysis bullosa in horses is also provided based on the determination that a mutation in the laminin .gamma.2 gene in which a cytosine is inserted at position 1368 is associated with the disease.

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