C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 407/04 (2006.01) A61K 31/352 (2006.01) A61P 25/16 (2006.01) A61P 25/28 (2006.01) C07D 311/62 (2006.01)
Patent
CA 2499549
Methods for the synthesis, isolation, and purification of procyanidin B2 are disclosed. The synthetic methods utilize epicatechin as a starting material and produce procyanidin BZ in high yields. The isolation methods extract procyanidin B2 from a sample of bark powder from plant matter of the genus Uncaria. The isolated and/or synthesized procyanidin B2 is used to treat amyloid disease, such as Alzheimer's disease and Parkinson's disease. Pharmaceutical compositions containing the synthesized and/or isolated procyanidin B2 are also disclosed.
La présente invention concerne des procédés pour synthétiser, isoler et purifier de la procyanidine B2. Les procédés de synthèse font intervenir de l'épicatéchine comme substance de départ et permettent de produire de la procyanidine B2 avec des rendements élevés. Les procédés d'isolation font intervenir l'extraction de procyanidine B2 d'un échantillon de poudre d'écorce obtenue à partir de la matière végétale du genre Uncaria. La procyanidine B2 isolée et/ou synthétisée est utilisée pour traiter les maladies liées à l'amyloïde telles que la maladie d'Alzheimer et la maladie de Parkinson. L'invention a également pour objet des compositions pharmaceutiques contenant la procyanidine B2 synthétisée et/ou isolée.
Castillo Gerardo M.
Choi Paula Y.
Larsen Lesley
Lorimer Stephen D.
Nguyen Beth P.
Proteotech Inc.
Smart & Biggar
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