Isomigrastatin analogs in the treatment of cancer

Details Isomigrastatin analogs in the treatment of cancer Isomigrastatin analogs in the treatment of cancer

C - Chemistry, Metallurgy

07

D

C07D 313/00 (2006.01) A61K 31/365 (2006.01) A61P 35/00 (2006.01)

Patent

CA 2582766

The present invention provides compounds having formula (I): (I) wherein n, R1- R5, Ra-Rb, Q, Y1 and Y2 are as defined herein; and additionally provides methods for the synthesis thereof, compositions thereof, and methods for the use thereof in the treatment of various disorders including cancer, metastasis and disorders involving increased angiogenesis.

La présente invention concerne des composés ayant la formule (I) où n, R1-R5, Ra-Rb, Q, Y1 et Y2 ont la définition donnée. L'invention concerne également des procédés de synthèse de ces composés, leurs compositions et leurs procédés d'utilisation dans le traitement de divers troubles, y compris le cancer, la tumeur métastatique et les troubles impliquant une angiogénèse accrue.

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