C - Chemistry – Metallurgy – 07 – C
Patent
C - Chemistry, Metallurgy
07
C
C07C 235/60 (2006.01) A61K 31/166 (2006.01) A61K 31/194 (2006.01) A61K 31/235 (2006.01) A61K 31/36 (2006.01) A61K 31/433 (2006.01) A61P 1/00 (2006.01) A61P 9/00 (2006.01) A61P 19/00 (2006.01) A61P 35/00 (2006.01) C07C 69/80 (2006.01) C07C 69/90 (2006.01) C07C 69/92 (2006.01) C07C 229/60 (2006.01) C07C 233/66 (2006.01) C07C 233/69 (2006.01) C07C 233/73 (2006.01) C07C 233/75 (2006.01) C07C 233/78 (2006.01) C07D 213/30 (2006.01) C07D 285/14 (2006.01) C07D 317/54 (2006.01)
Patent
CA 2435376
Selective MMP-13 inhibitors are isophthalic acid derivatives of the formula (I) wherein: R1, R2, and R3 independently are hydrogen, halo, hydroxy, C1-C6 alkyl, C1-C6 alkoxy, C2-C6 alkenyl, C2-C6 alkynyl, NO2, NR4R5, CN, or CF3; E is independently O or S; A and B independently are OR4 or NR4R5; each R4 and R5 independently are H, C1-C6 alkyl, C2-C6 alkenyl, C2-C6 alkynyl, (CH2)n aryl, (CH2)n cycloalkyl, (CH2)n heteroaryl, or R4 and R5 when taken together with the nitrogen to which they are attached complete a 3- to 8-membered ring, optionally containing heteroatom selected from O, S, or NH, and optionally substituted or unsubstituted; n is 0 to 6; or a pharmaceutically acceptable salt thereof. The compounds are useful for treating diseases in a mammal that are mediated by MMP enzymes.
L'invention concerne des inhibiteurs MMP-13 sélectifs qui sont des dérivés d'acide isophthalique de formule (I). Dans cette formule, R?1¿, R?2¿, et R?3¿ représentent indépendamment l'hydrogène, l'halogène, un hydroxy, C¿1?-C¿6? alkyle, C¿1?-C¿6? alcoxy, C¿2?-C¿6? alcényle, C¿2?-C¿6? alkynyle, NO¿2?, NR?4¿R?5¿, CN, ou CF¿3?, E représente indépendamment O ou S, A et B représentent indépendamment OR?4¿ ou NR?4¿R?5¿, R?4¿ et R?5¿ représentent respectivement et indépendamment H, C¿1?-C¿6? alkyle, C¿2?-C¿6? alcényle, C¿2?-C¿6? alkynyle, (CH¿2?)¿n? aryle, (CH¿2?)¿n? cycloalkyle, (CH¿2?)¿n? hétéroaryle, ou R?4¿ et R?5¿, lorsqu'ils sont avec l'azote auquel ils sont attachés, complètent un anneau comprenant 3 à 8 éléments, contenant facultativement un hétéroaome sélectionné parmi O, S, ou NH, et facultativement substitué ou non substitué, n est un nombre entier compris entre 0 et 6, ou un sel correspondant acceptable pharmaceutiquement. On utilise les composés pour traiter des maladies chez un mammifère, lesdits composés étant médiés par des enzymes MMP.
Barvian Nicole Chantel
Connor David Thomas
Dyer Richard Dennis
Johnson Adam Richard
Patt William Chester
Sim & Mcburney
Warner-Lambert Company Llc
LandOfFree
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