Isoprenoid phospholipase a2 inhibitors and preparations...

Details Isoprenoid phospholipase a2 inhibitors and preparations... Isoprenoid phospholipase a2 inhibitors and preparations...

C - Chemistry, Metallurgy

07

C

C07C 403/24 (2006.01) A61K 31/19 (2006.01) A61K 31/235 (2006.01) C07C 63/64 (2006.01) C07C 403/20 (2006.01)

Patent

CA 2051766

ABSTRACT OF THE DISCLOSURE: Compounds of the formula Image (A) wherein R1 is CH=CY-C ( CH3 ) =CHX wherein X and Y are different and each is of the formula Image wherein R' and R" independently are H or alkyl of C1-6 and R1 includes all possible geometric isomers. are demonstrated effective in treating inflammation, both topically and internally. The mechanism appears to be the inhibition of phospholipase A2 enzymes.

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