Isoquinoline compounds and medicinal use thereof

Details Isoquinoline compounds and medicinal use thereof Isoquinoline compounds and medicinal use thereof

C - Chemistry, Metallurgy

07

D

C07D 217/24 (2006.01) A61K 31/472 (2006.01) A61K 31/4725 (2006.01) A61K 31/4745 (2006.01) A61K 31/496 (2006.01) A61K 31/5377 (2006.01) A61P 9/00 (2006.01) A61P 9/10 (2006.01) A61P 43/00 (2006.01) C07D 401/04 (2006.01) C07D 401/06 (2006.01) C07D 471/04 (2006.01) C07D 498/04 (2006.01) C07D 513/04 (2006.01)

Patent

CA 2507027

Isoquinoline compounds represented by the following general formula (I) or (II) and their optically active isomers, pharmaceutically acceptable salts thereof, water adducts thereof, hydrates thereof and solvates thereof. Preventives and/or remedies for diseases caused by hyperfunction of poly(ADP- ribose) synthase which contain the above compounds and poly(ADP-ribose) synthase inhibitors containing the above compounds. These compounds are useful as preventives and/or remedies for cerebral infarction, in particular, preventives and/or remedies for cerebral infarction in the acute stage. (I) (II) .

L'invention concerne des composés d'isoquinolinone de formule générale (I) ou (II) et leurs isomères optiquement actifs, leurs sels pharmaceutiquement acceptables, leurs adduits à base d'eau, leurs hydrates et solvates. Elle concerne également des produits à action préventive et/ou thérapeutique contre des maladies causées par l'hyperfonction de la poly(ADP-ribose) synthase, qui contiennent les composés de l'invention. Elle concerne aussi des inhibiteurs de la poly(ADP-ribose) synthase contenant ces composés. Les composés de l'invention sont utiles comme produits à action préventive et/ou thérapeutique contre l'infarctus cérébral, en particulier l'infarctus cérébral au stade aigu.

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