Isoquinoline compounds and medicinal use thereof

Details Isoquinoline compounds and medicinal use thereof Isoquinoline compounds and medicinal use thereof

C - Chemistry, Metallurgy

07

D

C07D 401/04 (2006.01) A61K 31/4725 (2006.01) A61P 9/00 (2006.01) A61P 25/00 (2006.01) A61P 43/00 (2006.01) C07D 207/08 (2006.01) C07D 207/12 (2006.01) C07D 401/06 (2006.01) C07D 405/04 (2006.01) C07D 405/06 (2006.01) C07D 405/12 (2006.01)

Patent

CA 2500888

An isoquinoline compound represented by the following general formula (1): (1) its optically active isomers, pharmaceutically acceptable salts thereof, water- adducts thereof, hydrates thereof and solvates thereof; a preventive and/or a remedy for a disease caused by the hyperfunction of poly(ADP-ribose) synthase which contains the above compound; and a poly(ADP-ribose) synthase inhibitor which contains the above compound. This compound is also useful as a preventive and/or a remedy for brain infarction, in particular, a preventive and/or a remedy for brain infarction in the acute stage. Moreover, it is useful as a preventive and/or a remedy for improving nerve symptoms accompanying brain infarction, in particular, brain infarction in the acute stage.

L'invention porte sur un composé d'isoquinoline représenté par la formule générale (I), sur ses isomères optiquement actifs, ses sels acceptables d'un point de vue pharmaceutique, ses produits d'addition d'eau, ses hydrates et ses solvates. L'invention porte également sur un agent prophylactique et/ou thérapeutique d'une maladie provoquée par l'hyperfonction de la poly(ADP-ribose)synthase contenant le composé précité, et sur un inhibiteur de la poly(ADP-ribose)synthase. Ce composé est également utile comme agent prophylactique et/ou thérapeutique dans la formation d'un infarctus cérébral en phase aiguë. Ce composé est, de plus, utile comme agent prophylactique et/ou thérapeutique en vue d'améliorer les symptômes nerveux accompagnant la formation d'un infarctus cérébral, notamment, en phase aiguë.

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