C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 217/24 (2006.01) A61K 31/472 (2006.01) A61P 25/16 (2006.01)
Patent
CA 2483461
This invention relates to isoquinolino derivatives of the general Formula (I) wherein Y is >C=O or CH2-, Z is >C=O or CH2-, and R1, R2 and m are as defined in the specification, as well as their pharmaceutically acceptable salts. The invention further relates to medicaments containing these compounds, a process for their preparation as well as their use for preparation of medicaments for the treatment or prevention of diseases in which MAO-B inhibitors might be beneficial.
L'invention se rapporte à des dérivés d'isoquinoléine de formule (I), dans laquelle Y représente >C=O ou CH¿2?-, Z représente >C=O ou CH¿2?-, et R?1¿, R?2¿ et m sont tels que définis dans la description, ainsi que leurs sels pharmaceutiquement acceptables. L'invention se rapporte en outre à des médicaments contenant ces composés, à leur procédé de préparation ainsi qu'à leur utilisation dans la préparation de médicaments pour le traitement ou la prévention de maladies dans lesquelles les inhibiteurs MAO-B peuvent avoir des effets bénéfiques.
Cesura Andrea
Rodriguez Sarmiento Rosa Maria
Scalone Michelangelo
Thomas Andrew William
Wyler Rene
Borden Ladner Gervais Llp
F. Hoffmann-La Roche Ag
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