Isoquinoline derivatives

C - Chemistry – Metallurgy – 07 – D

Patent

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Details

C07D 401/12 (2006.01) A61P 35/04 (2006.01) C07D 217/12 (2006.01) C07D 217/16 (2006.01) C07D 403/12 (2006.01)

Patent

CA 2478618

Disclosed are isoquinoline derivatives of general formula (I), in which X, Y, Z, R1, R2, and n have the meanings indicated in claim (1), and the physiologically acceptable salts or solvates thereof, which are integrin inhibitors and can be used for the prevention of thromboses, heart attack, coronary heart diseases, arteriosclerosis, inflammations, tumors, osteoporosis, infections, and post-angioplasty restenosis or in pathological processes that are entertained or propagated by angiogenesis.

L'invention concerne des dérivés d'isoquinoléine de formule générale (I), dans laquelle X, Y, Z, R?1¿, R?2¿ et n ont les significations indiquées dans la revendication 1, ainsi que les sels ou solvates physiologiquement acceptables desdits dérivés. Ces dérivés d'isoquinoléine, qui sont des inhibiteurs de l'intégrine, peuvent être utilisés contre les thromboses, les infarctus cardiaques, les maladies cardiaques coronaires, l'artériosclérose, les inflammations, les tumeurs, l'ostéoporose, les infections et la resténose post-angioplastie ou dans le cas de phénomènes pathologiques entretenus ou propagés par l'angiogénèse.

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