Isoquinoline derivatives and process for the production thereof

Details Isoquinoline derivatives and process for the production thereof Isoquinoline derivatives and process for the production thereof

C - Chemistry, Metallurgy

07

D

260/246.2, 260/2

C07D 401/06 (2006.01) C07D 217/00 (2006.01) C07D 217/14 (2006.01) C07D 217/26 (2006.01) C07D 295/14 (2006.01)

Patent

CA 1053675

ABSTRACT OF THE DISCLOSURE Novel isoquinoline derivatives of the formula Image wherein R1 and R2 collectively are a C-N bond or R1 is H and R2 is H or R8 wherein R8 is alkanoyl of 1-10 carbon atoms, benzoyl, methoxybenzoyl, alkyl of 1-4 carbon atoms, or the corresponding alkyl substituted by phenyl, OH, ArCOO-, ArCOHN-, piperidino, 3,4-dehydropiperidino, morpholino, carboxy, carbomethoxy or carbethoxy, R3 is H, methyl or ethyl, R4 and R5 each are H or collectively a C-C bond; R6 and R7 each are H or methoxy, and Ar is 3,4,5-trimethoxy- phenyl, and the physiologically acceptable acid addition salts and quaternary ammonium salts thereof, have cardiovascular activity and can be prepared by acylating a corresponding primary amine lacking the COAr group with 3,4,5-trimethoxybenzoic acid or a functional derivative thereof.

215386

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