Isoquinoline derivatives and their therapeutical use

Details Isoquinoline derivatives and their therapeutical use Isoquinoline derivatives and their therapeutical use

C - Chemistry, Metallurgy

07

D

C07D 401/12 (2006.01) A61K 31/47 (2006.01) C07D 217/06 (2006.01)

Patent

CA 2309905

Carboxamides of general formula (I) are useful for the treatment and/or prophylaxis of anxiety, mania, depression disorders associated with a subarachnoid haemorrhage or neural shock, the effects associated with withdrawal from substances of abuse such as cocaine, nicotine, alcohol and benzodiazepines, disorders treatable and/or preventable with anti-convulsive agents, such as epilepsy including post-traumatic epilepsy, Parkinson's disease, psychosis, migraine, cerebral ischaemia, Alzheimer's disease and other degenerative diseases such as Huntingdon's chorea, schizophrenia, obsessive compulsive disorders (OCD), neurological deficits associated with AIDS, sleep disorders (including circadian rhythm disorders, insomnia & narcolepsy), tics (e.g. Giles de la Tourette's syndrome), traumatic brain injury, tinnitus, neuralgia, especially trigeminal neuralgia, neuropathic pain, dental pain, cancer pain, inappropriate neuronal activity resulting in neurodysthesias in diseases such as diabetes, multiple sclerosis (MS) and motor neurone disease, ataxias, muscular rigidity (spasticity), temporomandibular joint dysfunction, panic disorders and/or aggression.

L'invention porte sur des carboxamides de la formule générale (I) qui sont utilisés dans le traitement et/ou la prophylaxie de l'anxiété, des manies, des maladies dépressives associées à une hémorragie sous-arachnoïdienne ou choc neural, des effets associés à l'élimination de substances toxiques telles que la cocaïne, la nicotine, l'alcool et les benzodiazépines, les maladies pouvant être traitées et/ou prévenues par des agents anticonvulsion telles que l'épilepsie, y compris l'épilepsie post-traumatique, la maladie de Parkinson, la psychose, la migraine, l'ischémie cérébrale, la maladie d'Alzheimer et autres maladies dégénératives telles que la chorée d'Huntingdon, la schizophrénie, les troubles obsessivo-compulsifs, les déficiences neurologiques associées au SIDA, les troubles du sommeil (y compris les troubles du rythme circadien, l'insomnie et la narcolepsie), les tics (tels que le maladie de Gilles de la Tourette), les lésions traumatiques du cerveau, l'acouphène, les névralgies, notamment les névralgies faciales, la douleur névropathique, les douleurs dentaires, les douleurs cancéreuses, l'activité neuronale inappropriée résultant de neurodysthésies dans les maladies telles que les diabètes, la sclérose en plaques et la maladie du motoneurone, l'ataxie, les spasmes musculaires (spacticité), la dysfonction temporo-mandibulaire, les troubles paniques et/ou le comportement agressif.

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