Isoquinoline derivatives or salts thereof

Details Isoquinoline derivatives or salts thereof Isoquinoline derivatives or salts thereof

C - Chemistry, Metallurgy

07

D

C07D 401/06 (2006.01) A61K 31/4725 (2006.01) A61K 31/538 (2006.01) A61P 9/10 (2006.01) C07D 401/14 (2006.01) C07D 405/14 (2006.01) C07D 413/14 (2006.01) C07D 417/14 (2006.01)

Patent

CA 2373880

The present invention relates to a novel isoquinoline derivative or its salt having the following formula: (see formula I) wherein: A: lower alkylene; B: -C(=O) -NR5- or -NR5-C (=O)-; R1 and R2: hydrogen atom, lower alkyl or -O-lower alkyl, which may be the same or different; R3, R4 and R5: hydrogen atom or lower alkyl, which may be the same or different; ring D: optionally substituted hydrocarbon ring or optionally substituted hetero ring; m: 1, 2 or 3; n: O or 1; and q: 1 or 2. The isoquinoline derivative has an I f current inhibitory effect without serious side effects and is particularly useful as a cardiac rate lowering agent for preventing ischemic heart diseases such as angina and cardiac infarction and circulatory diseases such as congestive cardiac insufficiency and arrhythmia.

Cette invention concerne des dérivés d'isoquinoline représentés par la formule générale (I) ou leurs sels. Ces composés ont une action inhibitrice sur le courant If, sans effets secondaires sérieux du type convulsions. L'invention concerne également des médicaments, en particulier des abaisseurs de rythme cardiaque renfermant ces composés comme principe actif. Il s'agit en l'occurrence des dérivés de dialkoxy-1,2,3,4-tétrahydroquinoline-2carbonylpiperidino-3,4-dialkoxypropananilide, etc. qui ont une activité inhibitrice sur le courant If et qui conviennent comme abaisseurs de rythme cardiaque, en particulier pour la prévention des cardiopathies ischémiques telles que l'anxiété thoracique précordiale) et l'infarctus du myocarde ainsi que les troubles circulatoires tels que l'insuffisance cardiaque globale et l'arythmie (arythmie supraventriculaire, etc.).

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